2006 Ohio Student Research Forum

Abstract

Mechanical Properties of Electrospun Nanofiber
Theron van Putten
Ohio State University
Department of Chemical Engineering
Mentor: Dr. Sarah Drilling, John Lannutti

In the design of tissue engineered blood vessel grafts, the mechanical properties of the electrospun polycaprolactone scaffold are critical to biological acceptance. The graft constructed from this biodegradable polymer must have specific mechanical properties to ensure its success in the body by minimizing thrombosis and occlusion of the blood vessel. This study will focus on the tensile properties of the graft. The two main areas of research will be to: (1) correlate a new loadframe with an older model, comparing the tensile properties of both dogbone tensile bars and cylindrical scaffolds, and (2) study the effects of exposure to bioactive solutions on tensile properties. Ultimately the comparison of the dogbone and cylindrical scaffolds will provide greater insight into the tensile properties of the graft in both the longitudinal and circumferential directions, as well as a correlation to the burst strength of the graft. This awareness may help medical professionals give more sophisticated care if tissue engineered blood vessel grafts are to be used to perform complex heart operations, including coronary infarctions and bypass surgeries

Posted 9.22.06
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Updated 07-Jan-2008